Lewis S. Rosenstiel Award for
Distinguished Work in Basic Medical Science


Past Winners

2012

"for elucidating how eukaryotic cells sense and respond to DNA damage"

Stephen J. Elledge
Investigator, Howard Hughes Medical Institute
Senior Geneticist, Brigham and Womens Hospital
Gregor Mendel Professor of Genetics
Professor of Medicine
Harvard Medical School
Boston, MA USA


2011

"for his transformative studies of the control of protein synthesis in mammalian cells"

Nahum Sonenberg
James McGill Professor
Department of Biochemistry
Rosalind and Morris Goodman Cancer Research Centre
McGill University
Montreal, Canada


2010

"for their discovery that histones and histone acetylation directly regulate transcription"

C. David Allis
Tri-Institutional Professor
Joy and Jack Fishman Professor
Laboratory of Chromatin Biology and Epigenetics
The Rockefeller University
New York, NY USA
Michael Grunstein
Distinguished Professor, Biological Chemistry
Department of Biological Chemistry
The University of California, Los Angeles
Los Angeles, CA USA


2009

"for elucidating the mechanisms of innate immunity"

Jules Hoffman
(2011 Nobel Prize)
Professor and Distinguished Class Research Director
Institute of Molecular and Cellular Biology, CNRS
University Louis Pasteur
Strasbourg, France
Ruslan Medzhitov
David W. Wallace Professor of Immunobiology
Investigator, Howard Hughes Medical Institute
Yale School of Medicine
New Haven, CT USA


2008

"for their pioneering work in the field of stem cell research"

John Gurdon
(2012 Nobel Prize)
Professor
Department of Zoology
Gurdon Institute
University of Cambridge
Cambridge, England
Irving Weissman
Professor of Pathology and Developmental Biology
Director, Stem Cell Biology and Regenerative Medicine Institute
Stanford University School of Medicine
Stanford, CA USA
Shinya Yamanaka
(2012 Nobel Prize)
Professor, Institute for Frontier Medical Sciences
Kyoto University
Kyoto, Japan
Senior Investigator, Gladstone Institute of Cardiovascular Disease
Professor of Anatomy
The University of California, San Francisco
San Francisco, CA USA


2007

"for their pioneering work in the field of protein-mediated protein folding"

F.-Ulrich Hartl
Director
Max Planck Institute of Biochemistry
Martinsried, Germany
Arthur L. Horwich
Eugene Higgins Professor of Genetics and Pediatrics
Investigator, Howard Hughes Medical Institute
Yale School of Medicine
New Haven, CT USA


2006

"for their pioneering work on epigenetic gene regulation in mammalian embryos"

Mary Lyon
Mammalian Genetics Unit
MRC Harwell
Oxfordshire, England
Davor Solter
Department Head and Director
Max Planck Institute of Immunobiology
Freiburg, Germany
Azim Surani
Marshall-Walton Professor
Gurdon Institute
University of Cambridge
Cambridge, England


2005

"for their pioneering development of powerful new tools that allow the direct visualization of molecules in living cells"

Martin Chalfie
(2008 Nobel Prize)
William R. Kenan, Jr., Professor of Biological Sciences
Columbia University
New York, NY USA
Roger Y. Tsien
(2008 Nobel Prize)
Professor of Pharmacology and Chemistry & Biochemistry
The University of California, San Diego
La Jolla, CA USA


2004

"for their pioneering achievements in the discovery of gene silencing by double-stranded RNA"

Andrew Z. Fire
(2006 Nobel Prize)
Professor of Pathology and Genetics
Stanford University School of Medicine
Stanford, CA USA
Craig C. Mello
(2006 Nobel Prize)
Assistant Investigator, Howard Hughes Medical Institute
Professor, Program in Molecular Medicine
University of Massachusetts Medical School
Worcester, MA USA
Victor Ambros
Professor of Genetics
Dartmouth Medical School
Hanover, NH USA
Gary Ruvkun
Professor of Genetics
Massachusetts General Hospital
Boston, MA USA


2003

"for their pioneering achievements in the ethology and neurology of birdsong"

Masakzu Konishi
Bing Professor of Behavioral Biology
California Institute of Technology
Pasadena, CA USA
Peter R. Marler
Professor (emeritus)
Animal Communication Laboratory
The University of California, Davis
Davis, CA USA
Fernando Nottebohm
Dorothea L. Leonhardt Professor
Head, Laboratory of Animal Behavior
Director, Field Research Center
The Rockefeller University
New York, NY USA


2002

"for his pioneering achievements in yeast genetics and cell biology"

Ira Herskowitz
Professor of Biochemistry and Biophysics and
Codirector, Program in Human Genetics
The University of California, San Francisco
San Francisco, CA USA


2001

"for her work in establishing a sub-field of molecular biology concerning small nuclear ribonucleoproteins"

Joan A. Steitz
Sterling Professor of Molecular Biophysics and Biochemistry
Investigator, Howard Hughes Medical Institute
Yale University
New Haven, CT USA


2000

"for their discovery that peptide bond formation on the ribosome is catalyzed exclusively by ribosomal RNA"

Peter B. Moore
Eugene Higgins Professor of Chemistry and Molecular Biophysics and Biochemistry
Yale University
New Haven, CT USA
Harry F. Noller, Jr.
Robert L. Sinsheimer Professor of Molecular Biology
The University of California, Santa Cruz
Santa Cruz, CA USA
Thomas A. Steitz
(2009 Nobel Prize)
Eugene Higgins Professor of Molecular Biophysics and Biochemistry, and Chemistry
Investigator, Howard Hughes Medical Institute
Yale University
New Haven, CT USA


1999

"for his research into the molecular foundations of electrical signal generation in neurons and other types of cells"

Roderick MacKinnon
(2003 Nobel Prize)
John D. Rockefeller Jr. Professor of Molecular Neurobiology and Biophysics
Investigator, Howard Hughes Medical Institute
The Rockefeller University
New York, NY USA


1998

"for their outstanding work on the maintenance of telomeres"

Elizabeth Blackburn
(2009 Nobel Prize)
Professor of Microbiology and Immunology
The University of California, San Francisco
San Francisco, CA USA
Carol Greider
(2009 Nobel Prize)
Associate Professor of Molecular Biology and Genetics
Johns Hopkins University School of Medicine
Baltimore, MD USA


1997

"for their pioneering studies of cell lineage in the nematode worm"

H. Robert Horvitz
(2002 Nobel Prize)
Professor of Biology
Investigator, Howard Hughes Medical Institute
Massachusetts Institute of Technology
Cambridge, MA USA
John E. Sulston
(2002 Nobel Prize)
Director, The Sanger Centre
Wellcome Trust Genome Campus
Hinxton, England


1996

"for establishing the molecular basis of the senses of smell and hearing"

Richard Axel
(2004 Nobel Prize)
Higgins Professor of Biochemistry and Molecular Biophysics
Professor of Pathology
Investigator, Howard Hughes
Medical Institute
College of Physicians and Surgeons of Columbia University School of Medicine
New York, NY USA
Linda B. Buck
(2004 Nobel Prize)
Associate Professor of Neurobiology
Assistant Investigator, Howard Hughes
Medical Institute
Harvard Medical School
Boston, MA USA
A. James Hudspeth
Professor and Head, Laboratory of
Sensory Science
Investigator, Howard Hughes
Medical Institute
The Rockefeller University
New York, NY USA


1995

"for their fundamental contributions to our understanding of molecular motors"

Thomas D. Pollard
Halsted Professor of Cell Biology and Anatomy
Johns Hopkins University School of Medicine
Baltimore, MD USA
James A. Spudich
Professor of Biochemistry and Developmental Biology
Stanford University School of Medicine
Stanford, CA USA


1994

"for their outstanding work on eukaryotic transcription regulation"

Robert Roeder
Professor and Head, Laboratory of Biochemistry
and Molecular Biology
The Rockefeller University
New York, NY USA
Robert Tijan
Professor of Molecular and Cell Biology
Investigator, Howard Hughes Medical Institute
The University of California, Berkeley
Berkeley, CA USA


1993

"for determining the components of the secretory pathway"

James E. Rothman
(2013 Nobel Prize)
Chair, Cellular Biochemistry and Biophysics Program
Memorial Sloan-Kettering Cancer Center
New York, NY USA
Randy Schekman
(2013 Nobel Prize)
Professor of Molecular and Cell Biology
Investigator, Howard Hughes Medical Institute
The University of California, Berkeley
Berkeley, CA USA


1992

"for establishing the details of the control of the eukaryotic cell cycle"

Paul Nurse, F.R.S.
(2001 Nobel Prize)

Napier Royal Society Professor of Biochemistry
University of Oxford
Oxford, England
Leland H. Hartwell
(2001 Nobel Prize)

Professor, Department of Genetics
University of Washington
Seattle, WA USA


1991

"for creating the methods by which variations in the human genome can be detected and analyzed"

David Botstein
Chairman, Department of Genetics
Stanford University School of Medicine
Stanford, CA USA
Raymond L. White
Professor of Human Genetics
Investigator, Howard Hughes Medical Institute
University of Utah
Salt Lake City, UT USA
Ronald W. Davis
Professor of Biochemistry and Genetics
Stanford University School of Medicine
Stanford, CA USA


1990

"for determining the first structure of an integral membrane protein"

Richard Henderson, F.R.S.
Research Staff, Structural Studies Division
MRC Laboratory of Molecular Biology
Cambridge, England
Peter Nigel Tripp Unwin, F.R.S.
Research Staff, Division of Neurobiology
MRC Laboratory of Molecular Biology
Cambridge, England


1989

"for pioneering studies of eukaryotic development"

Christiane Nüsslein-Volhard
(1995 Nobel Prize)

Director, Max-Planck-Institut für Entwicklungsbiologie
Tübingen, Germany
Edward B. Lewis
(1995 Nobel Prize)

Thomas Hunt Morgan Professor of Biology (emeritus)
California Institute of Technology
Pasadena, CA USA


1988

"for discovering RNA catalysis"

Sidney Altman
(1989 Nobel Prize)

Dean of Yale College
Professor of Biology
Yale University
New Haven, CT USA
Thomas R. Cech
(1989 Nobel Prize)

American Cancer Society Professor
Investigator, Howard Hughes Medical Institute
University of Colorardo at Boulder
Boulder, CO USA


1987

"for his innovations in light microscopy"

Shinya Inoué
Distinguished Scientist
Marine Biological Laboratory
Woods Hole, MA USA


1986

"for his outstanding work on enzyme function"

Harland G. Wood
University Professor in Biochemistry (emeritus)
Case Western Reserve University
Cleveland, OH USA


1985

"for founding modern eukaryotic genetics"

Seymour Benzer
James Griffin Boswell Professor of Neuroscience
California Institute of Technology
Pasadena, CA USA
Sydney Brenner
(2002 Nobel Prize)
Laboratory of Molecular Biology
Medical Council Research Centre
University Medical School
Cambridge, England


1984

"for their seminal work on development"

Donald D. Brown
Adjunct Professor of Biology and Embryology
Johns Hopkins University
Baltimore, MD USA
Staff Member, Department of Embryology
Carnegie Institute of Washington
Cold Spring Harbor, NY USA
Robert L. Letsinger
Professor of Chemistry
Northwestern University
Evanston, IL USA


1983

"for pioneering contributions to sensory transduction"

Eric R. Kandel
(2000 Nobel Prize)
University Professor
College of Physicians and Surgeons
Columbia University
New York, NY USA
Daniel E. Koshland, Jr.
Professor of Biochemistry
The University of Califonia, Berkeley
Berkeley, CA USA


1982

Keith R. Porter
Professor of Cell Biology
University of Colorado at Boulder
Boulder, CO USA
Alexander Rich
William Thompson Sedgwick Professor of Biophysics
Massachusetts Institute of Technology
Cambridge, MA USA


1981

Stanley Cohen
(1986 Nobel Prize)

Professor of Biochemistry
Vanderbilt University
Nashville, TN USA
Rita Levi-Montalcini
(1986 Nobel Prize)

Laboratorio di Biologia Cellulare
Consiglio Nazionale delle Richerche
Rome, Italy
Gordon H. Sato
Professor of Biology
The University of California, San Diego
San Diego, CA USA


1980

Elias J. Corey
(1990 Nobel Prize)
Sheldon Emery Professor of Chemistry
Harvard University
Cambridge, MA USA
Bengt I. Samuelsson
(1982 Nobel Prize)

Dean of Medical Faculty
Kaolinska Institutet
Stockholm, Sweden
Frank H. Westheimer
Morris Loeb Professor of Chemistry
Harvard University
Cambridge, MA USA


1979

Howard Green
Professor of Cell Biology
Massachusetts Institute of Technology
Cambridge, MA USA
Beatrice Mintz
Senior Member
The Institute for Cancer Research
The Fox Chase Center
Philadelphia, PA USA


1978

César Milstein
(1984 Nobel Prize)

MRC Laboratory of Molecular Biology
Cambridge, England


1977

Barbara McClintock
(1983 Nobel Prize)

Distinguished Service Member
Carnegie Institution of Washington
Cold Spring Harbor, NY USA


1976

Peter D. Mitchell
(1978 Nobel Prize)

Glynn Research Laboratories
Bodmin, Cornwall, England


1975

Bruce Ames
Professor of Biochemistry
The University of California, Berkeley
Berkeley, CA USA
James A. and Elizabeth C. Miller
Professors of Oncology
University of Wisconsin-Madison
Madison, WI USA


1974

Arthur B. Pardee
Donner Professor of Science and Professor of Biochemistry and Biology
Princeton University
Princeton, NJ USA
H. Edwin Umbarger
Wright Distinguished Professor of Biological Sciences
Purdue University
West Lafayette, IN USA


1973

H. Ronald Kaback
Member
Roche Institute of Molecular Biology
Nutley, NJ USA
Rosenstiel Visiting Scholar
Saul Roseman
Professor, Department of Biology
McCollum-Pratt Institute
Johns Hopkins University
Baltimore, MD USA


1972

Boris Ephrussi
Honorary Director
Centre de Génétique Moléculaire, CNRS
Gif-sur-Yvette, France


1971

David H. Hubel
(1981 Nobel Prize)

George Packer Berry Professor of Neurobiology
Harvard Medical School
Boston, MA USA
Torsten N. Wiesel
(1981 Nobel Prize)

Professor of Neurobiology
Harvard Medical School
Boston, MA USA



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